Divalproex sodium Information
val PROE ik AS id & dah RIV ah tives
What is this drug used for?
– It is used to treat seizures.
– It is used to prevent migraine headaches.
– It is used to treat bipolar problems.
– It may be given to you for other reasons. Talk with the doctor.
Frequently reported side effects of this drug
– Abdominal pain
– Trouble sleeping
– Lack of appetite
– Increased hunger
– Weight gain
– Weight loss
– Flu-like signs
– Hair loss
Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:
– Liver problems like dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin.
– Pancreatitis like severe abdominal pain, severe back pain, severe nausea, or vomiting.
– Depression like thoughts of suicide, anxiety, emotional instability, or confusion.
– High ammonia level like abnormal heartbeat, abnormal breathing, confusion, pale skin, slow heartbeat, seizures, vomiting, or twitching.
– Chest pain
– Swelling of arms or legs
– Vision changes
– Trouble with memory
– Severe loss of strength and energy
– Change in balance
– Abnormal gait
– Purple or red spots on skin
– Unable to pass urine
– Change in amount of urine passed
– Swollen glands
– Panic attacks
– Mood changes
– Behavioral changes
– Muscle pain
– Muscle weakness
– Joint pain
– Joint swelling
– Involuntary eye movements
– Noise or ringing in the ears
– Cold sensation
– Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
Medication Safety Issues
Depakene may be confused with Depakote
Depakote may be confused with Depakene, Depakote ER, Senokot
Depakote ER may be confused with divalproex enteric coated
Valproate sodium may be confused with vecuronium
Storage and Stability
Immediate release: Store at 15?C to 25?C (59?F to 77?F).
Delayed release: Store at 25?C (77? F); excursions are permitted between 15?C and 30?C (59?F and 86?F).
Oral sprinkle capsules: Delayed release: Store below 25?C (77?F).
Oral solution: Immediate release: Store below 30?C (86?F).
Delayed release: Store below 30?C (86?F).
24-hour extended release: Store tablets at 25?C (77?F); excursions are permitted between 15?C and 30?C (59?F and 86?F).
Immediate release [Canadian product]: Store at 15?C and 25?C (59?F and 77?F). Protect from light.
IV: Store at controlled room temperature 15?C to 30?C (59?F to 86?F). Stable in D5W, NS, and LR for at least 24 hours when stored in glass or PVC.
As reported with oral administration, unless otherwise noted.
Cardiovascular: Chest pain, edema, facial edema, hypertension, hypotension, orthostatic hypotension, palpitations, peripheral edema, tachycardia, vasodilation (more common in oral)
Central nervous system: Abnormal dreams, abnormal gait, abnormality in thinking, agitation, amnesia, anxiety, ataxia, catatonia, chills, confusion, depression, dizziness (more common in oral), drowsiness (more common in oral), emotional lability, hallucination, headache (more common in oral), hyperreflexia, hypertonia, insomnia, malaise, myasthenia, nervousness (more common in oral), pain (more common in oral), paresthesia, personality disorder, sleep disorder, speech disturbance, tardive dyskinesia, twitching, vertigo
Dermatologic: Alopecia, diaphoresis, erythema nodosum, furunculosis, maculopapular rash, pruritus, seborrhea, skin rash, vesiculobullous dermatitis, xeroderma
Endocrine & metabolic: Amenorrhea, menstrual disease, weight gain, weight loss
Gastrointestinal: Abdominal pain (more common in oral), anorexia, constipation, diarrhea (more common in oral), dysgeusia, dyspepsia, dysphagia, eructation, fecal incontinence, flatulence, gastroenteritis, gingival hemorrhage, glossitis, hematemesis, hiccups, increased appetite, nausea (more common in oral), oral mucosa ulcer, pancreatitis, periodontal abscess, stomatitis, vomiting (more common in oral), xerostomia
Genitourinary: Cystitis, dysmenorrhea, dysuria, urinary frequency, urinary incontinence, vaginal hemorrhage, vaginitis
Hematologic & oncologic: Ecchymoses, hypoproteinemia, petechia, prolonged bleeding time, thrombocytopenia (dose related)
Hepatic: Increased serum alanine aminotransferase, increased serum aspartate aminotransferase
Infection: Fungal infection, infection, viral infection
Local: Injection site reaction, pain at injection site
Neuromuscular & skeletal: Arthralgia, asthenia, back pain, discoid lupus erythematosus, dysarthria, hypokinesia, lower limb cramps, myalgia, neck pain, neck stiffness, osteoarthritis, tremor
Ophthalmic: Conjunctivitis, diplopia, dry eye syndrome, eye pain, nystagmus disorder, photophobia, visual disturbance (amblyopia, blurred vision)
Otic: Deafness, otitis media, tinnitus
Respiratory: Bronchitis, cough, dyspnea, epistaxis, flu-like symptoms, pharyngitis (more common in oral), pneumonia, rhinitis, sinusitis
Miscellaneous: Accidental injury, fever
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